Low literacy levels in Africa are part-and-parcel of everyday life, and seriously reduce the effectiveness of health care literature. In association with the South African Depression and Anxiety Group, Books of Hope has designed and produced interactive, multilingual Speaking Books that can be seen, read, heard and understood regardless of someone’s reading ability. Each Speaking Book consists of 16 pages of culturally appropriate illustrations supported by straightforward and easy to understand text in a variety of languages. Every page has a corresponding push button that triggers a sound track read by a well-known local personality. So whatever a reader’s level of literacy, the information will be clearly understood. Topics include HIV and AIDS, TB, Malaria, Suicide Prevention and Diabetes. Speaking Books are distributed to rural and disadvantaged communities worldwide. This is a major breakthrough in presenting complex health issues in countries where low literacy levels are prevalent, giving everyone access to vital health care information. Of course the concept of a Speaking Book can be applied just as successfully to a wide range of needs, from educating children to providing instruction manuals for products or services.